List of top Pathology Questions

A patient is diagnosed with AML M3. Which chromosomal translocation is characteristically associated with this condition?
A patient has a neck mass with odynophagia and dyspnea. Histology shows amyloid deposition. What is the most likely diagnosis?
A middle-aged woman presents with dry eyes and dry mouth. Laboratory tests reveal positive anti-Ro (SSA) and anti-La (SSB) antibodies. What is the most likely underlying pathological mechanism?
A 68-year-old man presents with bleeding. Peripheral smear shows a “faggot cell.” Which translocation is associated?
A lymphoma characterized by centrocytes and centroblasts, along with BCL2 positivity and CD10 expression, is most commonly associated with which chromosomal translocation?
A 30-year-old man presents with a painless testicular mass. Ultrasound shows a well-circumscribed, homogeneous, non-hemorrhagic tumor. Histology is shown. What is the likely diagnosis?
Anti-Scl-70 antibody is most strongly associated with which condition?
Which of the following lab techniques is most commonly used to compare and quantify CD markers in cells?
A child presents with visual disturbances and delayed growth. Imaging reveals a suprasellar mass, and histopathology shows wet keratin compact, eosinophilic anucleate keratin. What is the most likely diagnosis?
A patient presents with hearing loss and balance problems. Histopathology of the lesion shows Antony A and Antony B areas and Verocay bodies. What is the most likely diagnosis?
A very tall man presents with visual problems and is found to have ectopia lentis on ophthalmological evaluation. Which gene is most likely defective in this patient?
A patient with history of cough, chest pain, and dyspnea has imaging that reveals giant cell granuloma formation and stellate inclusions. What is the likely diagnosis?
A 35-year-old woman undergoes abdominal imaging for nonspecific right upper quadrant pain. A liver mass is identified and surgically excised. The gross specimen is shown. What is the most likely diagnosis?
A 68-year-old man presents with persistent fatigue and generalized lymphadenopathy. CBC shows leukocytosis with an absolute lymphocyte count of 35,000/$\mu$L. Which investigation of choice confirms the diagnosis and determines CD markers of CLL?
Which of the following conditions is most likely to follow this pattern of inheritance?
Anti-mitochondrial antibody (AMA) is most commonly seen in which condition?
Which of the following types of cell death involves activation of caspase enzymes?
A 45-year-old male presents with discomfort in his joints. Synovial fluid aspiration reveals rhomboid-shaped positively birefringent crystals under polarized light microscopy. What is the most likely diagnosis?
A 65-year-old postmenopausal woman presents with bleeding per vagina. She undergoes a total hysterectomy. What is the most likely diagnosis?
Gross image of cystadenocarcinoma, CA-125 positive, and heaviness in abdomen is shown. What is the diagnosis?
A 14-year-old boy presents with fatigue, mild jaundice, and splenomegaly. His hemoglobin is 10.5 g/dL, MCV is 82 fL, and MCHC is high at 37 g/dL. His father had a similar history of chronic anemia and underwent splenectomy. What is the most likely diagnosis?
A patient collapses with breathlessness and pink frothy sputum. Autopsy shows hemosiderin-laden macrophages. In which condition is this not seen?
A 65-year-old man presents with enlarged hat size, shin pain, elevated alkaline phosphatase, and normal calcium and PTH levels. X-ray reveals mixed lytic and sclerotic bone lesions. What is the most likely diagnosis?
A 36-year-old woman with symmetrical small joint arthritis tests positive for anti-CCP. Which histological feature is most characteristic?
A male patient with recent history of RTA was brought to hospital. His CT scan was normal, but he died within three hours of admission. Autopsy revealed retraction ball appearance and petechial hemorrhages in the corpus callosum. What is the most likely diagnosis?