Question:
A 68-year-old man presents with bleeding. Peripheral smear shows a “faggot cell.” Which translocation is associated?
A 68-year-old man presents with bleeding. Peripheral smear shows a “faggot cell.” Which translocation is associated?
Show Hint
Faggot cells + bleeding/DIC = APL; translocation = t(15;17).
Updated On: May 14, 2026
- t(15;17)
- t(14;18)
- t(11;14)
- t(8;21)
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
Concept:
Faggot cells are promyelocytes containing bundles of Auer rods. They are characteristic of acute promyelocytic leukemia, also called AML M3, which is associated with t(15;17).
Step 1: Identify faggot cells.
Faggot cells contain multiple Auer rods and are seen in: \[ \text{Acute promyelocytic leukemia} \]
Step 2: Recall the genetic abnormality.
APL is caused by: \[ t(15;17) \] This forms the PML-RARA fusion gene.
Step 3: Connect with bleeding.
APL commonly presents with bleeding due to DIC. Therefore, the correct answer is t(15;17).
Step 1: Identify faggot cells.
Faggot cells contain multiple Auer rods and are seen in: \[ \text{Acute promyelocytic leukemia} \]
Step 2: Recall the genetic abnormality.
APL is caused by: \[ t(15;17) \] This forms the PML-RARA fusion gene.
Step 3: Connect with bleeding.
APL commonly presents with bleeding due to DIC. Therefore, the correct answer is t(15;17).
Was this answer helpful?
0
0
Top NEET PG Pathology Questions
- Which of the following is true regarding the Mendelian mode of inheritance?
- A child presents with intermittent jaundice and splenomegaly. There is a history of similar complaints in the elder brother. Peripheral smear shows the following finding. How will you investigate this condition?
- An African child is found to have a mass in the jaw. A biopsy of the mass was done, and it appears as shown in the image below. The child also had a translocation of t(8;14). What is the probable diagnosis?
- A child presented to the hospital with cola-colored urine, hypertension, and puffiness of eyes. Laboratory investigations were done, and creatinine was 2.5 mg/dL. Treatment was started, and despite treatment, the patient did not improve for the next 3 weeks. The creatinine value increased to 4.5 mg/dL. Which among the following electron microscopic findings will be seen in this patient ?
- A patient was transfused 4 units of blood 2 hours ago, and now she complains of chest discomfort. X-ray shows bilateral fissural thickening. Which of the following is the most probable cause ?
View More Questions
Top NEET PG Basic mechanisms of inflammation and repair Questions
- Contralateral loss of pain and temperature is due to injury to:
- IL- 1 activated by:
- 14 yr old child with Naive Rheumatoid Arthritis patient as shown in image . What should be the correct treatment of given condition:
- Stellate granuloma seen in
- Which of the following can result in dactylitis
View More Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions