Question:
A patient is diagnosed with AML M3. Which chromosomal translocation is characteristically associated with this condition?
A patient is diagnosed with AML M3. Which chromosomal translocation is characteristically associated with this condition?
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AML M3 or APL = t(15;17) and PML-RARA fusion.
Updated On: May 14, 2026
- t(9;22)
- t(8;21)
- t(15;17)
- t(11;14)
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The Correct Option is C
Solution and Explanation
Concept:
AML M3 is acute promyelocytic leukemia. It is characteristically associated with t(15;17), which produces the PML-RARA fusion gene.
Step 1: Identify AML subtype.
AML M3 means: \[ \text{Acute promyelocytic leukemia} \]
Step 2: Recall characteristic translocation.
The classical translocation is: \[ t(15;17) \]
Step 3: Understand clinical importance.
APL commonly causes DIC and bleeding, but responds well to ATRA therapy. Therefore, the correct answer is t(15;17).
Step 1: Identify AML subtype.
AML M3 means: \[ \text{Acute promyelocytic leukemia} \]
Step 2: Recall characteristic translocation.
The classical translocation is: \[ t(15;17) \]
Step 3: Understand clinical importance.
APL commonly causes DIC and bleeding, but responds well to ATRA therapy. Therefore, the correct answer is t(15;17).
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