Question

Anti-mitochondrial antibody (AMA) is most commonly seen in which condition?

• A. Autoimmune hepatitis
• B. Primary biliary cholangitis
• C. Primary sclerosing cholangitis
• D. Systemic lupus erythematosus

Hint:

AMA = Primary biliary cholangitis. p-ANCA = Primary sclerosing cholangitis.

Answer 1

The Correct Option is B

Concept: Anti-mitochondrial antibody is the characteristic autoantibody of primary biliary cholangitis. It is associated with autoimmune destruction of small intrahepatic bile ducts.

Step 1: Identify the antibody.
The antibody given is: \[ \text{Anti-mitochondrial antibody} \]

Step 2: Recall the association.
AMA is classically associated with: \[ \text{Primary biliary cholangitis} \]

Step 3: Differentiate from others.
Autoimmune hepatitis is associated with ANA, SMA, or anti-LKM antibodies. Primary sclerosing cholangitis is associated with p-ANCA. Therefore, the correct answer is Primary biliary cholangitis.