Question:
A 36-year-old woman with symmetrical small joint arthritis tests positive for anti-CCP. Which histological feature is most characteristic?
A 36-year-old woman with symmetrical small joint arthritis tests positive for anti-CCP. Which histological feature is most characteristic?
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Anti-CCP positive symmetrical small joint arthritis = rheumatoid arthritis; histology shows pannus formation.
Updated On: May 14, 2026
- Synovial granulomas
- Pannus formation and reactive lymphocytic infiltrate
- Uric acid crystal deposits
- Non-caseating granulomas
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The Correct Option is B
Solution and Explanation
Concept:
Symmetrical small joint arthritis with anti-CCP positivity strongly suggests rheumatoid arthritis. The characteristic pathological feature in rheumatoid arthritis is pannus formation.
Step 1: Identify the disease.
The patient has: \[ \text{Symmetrical small joint arthritis + anti-CCP positive} \] This is highly suggestive of: \[ \text{Rheumatoid arthritis} \]
Step 2: Recall the histology.
In rheumatoid arthritis, there is chronic synovial inflammation with proliferation of synovium. This forms: \[ \text{Pannus} \] Pannus can destroy cartilage and bone.
Step 3: Choose the characteristic feature.
The most characteristic histological feature is: \[ \text{Pannus formation and reactive lymphocytic infiltrate} \]
Step 1: Identify the disease.
The patient has: \[ \text{Symmetrical small joint arthritis + anti-CCP positive} \] This is highly suggestive of: \[ \text{Rheumatoid arthritis} \]
Step 2: Recall the histology.
In rheumatoid arthritis, there is chronic synovial inflammation with proliferation of synovium. This forms: \[ \text{Pannus} \] Pannus can destroy cartilage and bone.
Step 3: Choose the characteristic feature.
The most characteristic histological feature is: \[ \text{Pannus formation and reactive lymphocytic infiltrate} \]
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