Question:
A patient has a neck mass with odynophagia and dyspnea. Histology shows amyloid deposition. What is the most likely diagnosis?
A patient has a neck mass with odynophagia and dyspnea. Histology shows amyloid deposition. What is the most likely diagnosis?
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Thyroid tumor with amyloid stroma = medullary thyroid carcinoma.
Updated On: May 14, 2026
- Papillary thyroid carcinoma
- Follicular thyroid carcinoma
- Medullary thyroid carcinoma
- Anaplastic thyroid carcinoma
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The Correct Option is C
Solution and Explanation
Concept:
Medullary thyroid carcinoma arises from parafollicular C cells of the thyroid. It secretes calcitonin and is characteristically associated with amyloid deposition in the tumor stroma.
Step 1: Identify the histology clue.
The important clue is: \[ \text{Amyloid deposition} \]
Step 2: Connect with thyroid cancer type.
Amyloid deposition is classically seen in: \[ \text{Medullary thyroid carcinoma} \]
Step 3: Recall origin.
Medullary carcinoma arises from C cells and produces calcitonin. Therefore, the correct answer is Medullary thyroid carcinoma.
Step 1: Identify the histology clue.
The important clue is: \[ \text{Amyloid deposition} \]
Step 2: Connect with thyroid cancer type.
Amyloid deposition is classically seen in: \[ \text{Medullary thyroid carcinoma} \]
Step 3: Recall origin.
Medullary carcinoma arises from C cells and produces calcitonin. Therefore, the correct answer is Medullary thyroid carcinoma.
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