Question

Which of the following conditions is most likely to follow this pattern of inheritance?

• A. Prader-Willi syndrome
• B. Marfan syndrome
• C. Kearns-Sayre syndrome
• D. Duchenne muscular dystrophy

Hint:

Autosomal dominant pedigree usually shows vertical transmission in successive generations.

Answer 1

The Correct Option is B

Concept: Marfan syndrome follows an autosomal dominant pattern of inheritance. Autosomal dominant disorders often affect multiple generations and both males and females.

Step 1: Identify the likely inheritance pattern.
The pedigree pattern suggests vertical transmission, meaning the condition appears in successive generations.

Step 2: Recall Marfan inheritance.
Marfan syndrome is caused by mutation in the FBN1 gene and is inherited as: \[ \text{Autosomal dominant} \]

Step 3: Compare with other options.
Duchenne muscular dystrophy is X-linked recessive. Kearns-Sayre syndrome is mitochondrial. Prader-Willi syndrome involves imprinting defects. Therefore, the correct answer is Marfan syndrome.