Question:
Anti-Scl-70 antibody is most strongly associated with which condition?
Anti-Scl-70 antibody is most strongly associated with which condition?
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Anti-Scl-70 = diffuse systemic sclerosis with high risk of interstitial lung disease.
Updated On: May 14, 2026
- GAVE
- Calcinosis cutis
- Interstitial lung disease
- Myositis
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The Correct Option is C
Solution and Explanation
Concept:
Anti-Scl-70 antibody, also called anti-topoisomerase I antibody, is associated with diffuse systemic sclerosis. It is strongly linked with interstitial lung disease.
Step 1: Identify the antibody.
Anti-Scl-70 is a marker of systemic sclerosis, especially diffuse cutaneous systemic sclerosis.
Step 2: Recall major association.
A serious complication associated with anti-Scl-70 positivity is: \[ \text{Interstitial lung disease} \]
Step 3: Choose the best option.
Among the options, interstitial lung disease is most strongly associated with anti-Scl-70. Therefore, the correct answer is Interstitial lung disease.
Step 1: Identify the antibody.
Anti-Scl-70 is a marker of systemic sclerosis, especially diffuse cutaneous systemic sclerosis.
Step 2: Recall major association.
A serious complication associated with anti-Scl-70 positivity is: \[ \text{Interstitial lung disease} \]
Step 3: Choose the best option.
Among the options, interstitial lung disease is most strongly associated with anti-Scl-70. Therefore, the correct answer is Interstitial lung disease.
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