Question:
A lymphoma characterized by centrocytes and centroblasts, along with BCL2 positivity and CD10 expression, is most commonly associated with which chromosomal translocation?
A lymphoma characterized by centrocytes and centroblasts, along with BCL2 positivity and CD10 expression, is most commonly associated with which chromosomal translocation?
Show Hint
Follicular lymphoma = CD10 positive, BCL2 positive, t(14;18).
Updated On: May 14, 2026
- t(2;5)
- t(11;14)
- t(14;18)
- t(8;21)
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Concept:
Follicular lymphoma contains centrocytes and centroblasts and commonly expresses CD10 and BCL2. It is associated with t(14;18), causing BCL2 overexpression.
Step 1: Identify the lymphoma.
Centrocytes and centroblasts with CD10 positivity suggest: \[ \text{Follicular lymphoma} \]
Step 2: Recall the translocation.
Follicular lymphoma is classically associated with: \[ t(14;18) \]
Step 3: Understand BCL2 role.
This translocation causes increased BCL2 expression, preventing apoptosis. Therefore, the correct answer is t(14;18).
Step 1: Identify the lymphoma.
Centrocytes and centroblasts with CD10 positivity suggest: \[ \text{Follicular lymphoma} \]
Step 2: Recall the translocation.
Follicular lymphoma is classically associated with: \[ t(14;18) \]
Step 3: Understand BCL2 role.
This translocation causes increased BCL2 expression, preventing apoptosis. Therefore, the correct answer is t(14;18).
Was this answer helpful?
0
0
Top NEET PG Pathology Questions
- Which of the following is true regarding the Mendelian mode of inheritance?
- A child presents with intermittent jaundice and splenomegaly. There is a history of similar complaints in the elder brother. Peripheral smear shows the following finding. How will you investigate this condition?
- An African child is found to have a mass in the jaw. A biopsy of the mass was done, and it appears as shown in the image below. The child also had a translocation of t(8;14). What is the probable diagnosis?
- A child presented to the hospital with cola-colored urine, hypertension, and puffiness of eyes. Laboratory investigations were done, and creatinine was 2.5 mg/dL. Treatment was started, and despite treatment, the patient did not improve for the next 3 weeks. The creatinine value increased to 4.5 mg/dL. Which among the following electron microscopic findings will be seen in this patient ?
- A patient was transfused 4 units of blood 2 hours ago, and now she complains of chest discomfort. X-ray shows bilateral fissural thickening. Which of the following is the most probable cause ?
View More Questions
Top NEET PG Hematopathology Questions
- True about type 1 diabetes mellitus:
- What is the cause of intracorpuscular defects in hemolysis?
- Which is the following is orally active direct Xa inhibitor?
- Whole blood is used as a sample for which test?
- Identify the organism related to blood smear image :
View More Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions