Question:
A 68-year-old man presents with persistent fatigue and generalized lymphadenopathy. CBC shows leukocytosis with an absolute lymphocyte count of 35,000/$\mu$L. Which investigation of choice confirms the diagnosis and determines CD markers of CLL?
A 68-year-old man presents with persistent fatigue and generalized lymphadenopathy. CBC shows leukocytosis with an absolute lymphocyte count of 35,000/$\mu$L. Which investigation of choice confirms the diagnosis and determines CD markers of CLL?
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CLL confirmation and CD marker analysis = flow cytometry of peripheral blood.
Updated On: May 14, 2026
- Bone marrow biopsy
- Flow cytometry of peripheral blood
- Serum LDH levels
- Lymph node excisional biopsy
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The Correct Option is B
Solution and Explanation
Concept:
Chronic lymphocytic leukemia is commonly seen in elderly patients and presents with persistent lymphocytosis. Flow cytometry of peripheral blood confirms the diagnosis by identifying characteristic CD markers.
Step 1: Identify CLL clues.
The patient is elderly and has: \[ \text{Generalized lymphadenopathy + absolute lymphocytosis} \] This suggests CLL.
Step 2: Know the confirmatory test.
CLL diagnosis is confirmed by immunophenotyping using: \[ \text{Flow cytometry} \]
Step 3: Understand CD marker role.
Flow cytometry detects markers such as CD5, CD19, CD20, and CD23 on B cells. Therefore, the correct answer is Flow cytometry of peripheral blood.
Step 1: Identify CLL clues.
The patient is elderly and has: \[ \text{Generalized lymphadenopathy + absolute lymphocytosis} \] This suggests CLL.
Step 2: Know the confirmatory test.
CLL diagnosis is confirmed by immunophenotyping using: \[ \text{Flow cytometry} \]
Step 3: Understand CD marker role.
Flow cytometry detects markers such as CD5, CD19, CD20, and CD23 on B cells. Therefore, the correct answer is Flow cytometry of peripheral blood.
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