Question:
Long-term administration of NSAIDs may induce edema and increase inflammation due to
Long-term administration of NSAIDs may induce edema and increase inflammation due to
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No PG in kidney = No salt excretion = Edema.
Updated On: May 25, 2026
- Due to increase adrenal secretion
- Due to prostaglandin synthesis
- Due to Stimulation of sympathetic neurons
- Increased histamine release
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The Correct Option is B
Solution and Explanation
Step 1: Concept
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the enzyme Cyclooxygenase (COX).
Step 2: Meaning
Edema in this context is caused by the inhibition of renal prostaglandins ($PGE_{2}$ and $PGI_{2}$), which normally maintain renal blood flow and promote sodium excretion.
Step 3: Analysis
When COX is inhibited, the loss of these protective prostaglandins leads to sodium and water retention. While they reduce acute inflammation, the secondary effect on renal hemodynamics leads to fluid retention (edema).
Step 4: Conclusion
The primary mechanism for this adverse effect is the interference with prostaglandin synthesis. Final Answer: (B)
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the enzyme Cyclooxygenase (COX).
Step 2: Meaning
Edema in this context is caused by the inhibition of renal prostaglandins ($PGE_{2}$ and $PGI_{2}$), which normally maintain renal blood flow and promote sodium excretion.
Step 3: Analysis
When COX is inhibited, the loss of these protective prostaglandins leads to sodium and water retention. While they reduce acute inflammation, the secondary effect on renal hemodynamics leads to fluid retention (edema).
Step 4: Conclusion
The primary mechanism for this adverse effect is the interference with prostaglandin synthesis. Final Answer: (B)
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