Question:
The diuretic action of Triamterene on the distal convoluted tubule and collecting duct is due to inhibition of:
The diuretic action of Triamterene on the distal convoluted tubule and collecting duct is due to inhibition of:
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Triamterene "Tries" to block "Sodium" directly at the ENaC.
Updated On: May 25, 2026
- Sodium channel
- Potassium channel
- Calcium channel
- Chloride channel
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Triamterene belongs to the class of potassium-sparing diuretics.
Step 2: Meaning
Diuretics increase the excretion of water and electrolytes from the kidneys to manage conditions like hypertension or edema.
Step 3: Analysis
Triamterene acts by directly blocking the epithelial sodium channels (ENaC) on the luminal membrane of the late distal tubule and collecting duct. This prevents sodium reabsorption without being dependent on aldosterone.
Step 4: Conclusion
The inhibition of these sodium channels leads to decreased sodium reabsorption and, consequently, reduced potassium secretion. Final Answer: (A)
Triamterene belongs to the class of potassium-sparing diuretics.
Step 2: Meaning
Diuretics increase the excretion of water and electrolytes from the kidneys to manage conditions like hypertension or edema.
Step 3: Analysis
Triamterene acts by directly blocking the epithelial sodium channels (ENaC) on the luminal membrane of the late distal tubule and collecting duct. This prevents sodium reabsorption without being dependent on aldosterone.
Step 4: Conclusion
The inhibition of these sodium channels leads to decreased sodium reabsorption and, consequently, reduced potassium secretion. Final Answer: (A)
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