Question:
Adverse drug reaction of cyclophosphamide is a hemorrhagic cystitis is minimized by:
Adverse drug reaction of cyclophosphamide is a hemorrhagic cystitis is minimized by:
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MESNA "Mops" up the toxic acrolein in the bladder.
Updated On: May 25, 2026
- MESNA
- Leucovorin
- Decazoxazone
- Allopurinol
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Cyclophosphamide is an alkylating agent used in chemotherapy that produces a toxic metabolite called acrolein.
Step 2: Meaning
Hemorrhagic cystitis is an inflammation of the bladder characterized by bleeding, caused by the irritation of the bladder lining by acrolein.
Step 3: Analysis
Leucovorin is used for methotrexate rescue, and Allopurinol is for gout/hyperuricemia. MESNA (2-mercaptoethane sulfonate sodium) is a thiol compound that binds to and neutralizes acrolein in the bladder.
Step 4: Conclusion
Administering MESNA along with adequate hydration is the standard procedure to prevent cyclophosphamide-induced bladder toxicity. Final Answer: (A)
Cyclophosphamide is an alkylating agent used in chemotherapy that produces a toxic metabolite called acrolein.
Step 2: Meaning
Hemorrhagic cystitis is an inflammation of the bladder characterized by bleeding, caused by the irritation of the bladder lining by acrolein.
Step 3: Analysis
Leucovorin is used for methotrexate rescue, and Allopurinol is for gout/hyperuricemia. MESNA (2-mercaptoethane sulfonate sodium) is a thiol compound that binds to and neutralizes acrolein in the bladder.
Step 4: Conclusion
Administering MESNA along with adequate hydration is the standard procedure to prevent cyclophosphamide-induced bladder toxicity. Final Answer: (A)
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