Question:
In a two-compartment pharmacokinetic model, the central compartment represents which organ:
In a two-compartment pharmacokinetic model, the central compartment represents which organ:
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Central = Fast (Heart, Liver, Kidneys); Peripheral = Slow (Fat, Bone).
Updated On: May 25, 2026
- Ligaments
- Bone
- Heart
- Tendons
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The Correct Option is C
Solution and Explanation
Step 1: Concept
Pharmacokinetic compartmental models simplify the body into discrete sections based on the rate of drug distribution.
Step 2: Meaning
The "Central Compartment" consists of the blood (plasma) and highly perfused tissues where drug equilibrium is achieved almost instantaneously.
Step 3: Analysis
Tissues like bone, ligaments, and tendons are poorly perfused and belong to the peripheral compartment. The heart, lungs, liver, and kidneys receive high blood flow and are part of the central compartment.
Step 4: Conclusion
The heart is a highly perfused organ and thus represents the central compartment. Final Answer: (C)
Pharmacokinetic compartmental models simplify the body into discrete sections based on the rate of drug distribution.
Step 2: Meaning
The "Central Compartment" consists of the blood (plasma) and highly perfused tissues where drug equilibrium is achieved almost instantaneously.
Step 3: Analysis
Tissues like bone, ligaments, and tendons are poorly perfused and belong to the peripheral compartment. The heart, lungs, liver, and kidneys receive high blood flow and are part of the central compartment.
Step 4: Conclusion
The heart is a highly perfused organ and thus represents the central compartment. Final Answer: (C)
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