Question:
The relationship between pH of the environment, the pKa of drug, and extent of ionization
The relationship between pH of the environment, the pKa of drug, and extent of ionization
Show Hint
pH, pKa, and % Ionized? Use the H-H equation.
Updated On: May 25, 2026
- Noyes whitney equation
- Henderson-Hasselbalch equation
- Law of mass action
- Fick law
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Concept
Most drugs are weak acids or bases, and their absorption depends on their degree of ionization.
Step 2: Meaning
Ionization is determined by the pH of the biological medium and the dissociation constant (pKa) of the drug.
Step 3: Analysis
The Henderson-Hasselbalch equation relates these three variables: $pH = pKa + \log \frac{[\text{salt}]}{[\text{acid}]}$. This allows for the calculation of the ionized vs. unionized fractions.
Step 4: Conclusion
The Henderson-Hasselbalch equation is the fundamental tool for predicting drug ionization. Final Answer: (B)
Most drugs are weak acids or bases, and their absorption depends on their degree of ionization.
Step 2: Meaning
Ionization is determined by the pH of the biological medium and the dissociation constant (pKa) of the drug.
Step 3: Analysis
The Henderson-Hasselbalch equation relates these three variables: $pH = pKa + \log \frac{[\text{salt}]}{[\text{acid}]}$. This allows for the calculation of the ionized vs. unionized fractions.
Step 4: Conclusion
The Henderson-Hasselbalch equation is the fundamental tool for predicting drug ionization. Final Answer: (B)
Was this answer helpful?
0
0
Top GPAT Pharmacy Questions
- Glycogenic amino acids enter TCA cycle except:
- The most active estrogen found naturally in the human body is:
- The diuretic action of Triamterene on the distal convoluted tubule and collecting duct is due to inhibition of:
- Adverse drug reaction of cyclophosphamide is a hemorrhagic cystitis is minimized by:
- Ritodrine and Isoxsuprine work as a tocolytic by the:
View More Questions
Top GPAT Physical Pharmacy Questions
- Iodine is sparingly soluble in water that 1 part of solute dissolve in ______ how many parts of water
- According to United State Pharmacopoeia, 1 part of solute dissolves in 10-30 parts are
- Buffer most commonly used in ophthalmic preparation as
- Chemical penetration enhancer used in Transdermal formulation
- In pharmaceutical manufacturing, Laminar Air flow cabinet provides which class of clean air in aseptic technique
View More Questions
Top GPAT Questions
- Match the symbols in the List I with the terms used in the List II of conductance measurements, and
List I
SymbolsList II
TermsA \(\Omega^{-1}\) I Specific conductance B \(∧\) II Electrical conductance C k III Specific resistance D \(\rho\) IV Equivalent conductance
Choose the correct answer from the options given below: - Cottrell’s method is used for the measurement of:
- Match the statements in List I with their correct answers in List II, respectively, in respect to modified 1st law of thermodynamics, and
List I
List II
A Constant heat (q = 0) I Isothermal B Reversible process at constant temperature (dT = 0) II Isometric C Constant volume (dV = 0) III Adiabatic D Constant pressure (dP = 0) IV Isobar
Choose the correct answer from the options given below: - Boric acid with molecular weight 61.83 was partitioned between water and amyl alcohol at 25 °C. The amount of boric acid was determined to be 0.24 g in 250 ml of amyl alcohol and 0.32 g in 100 ml water. The partition coefficient of boric acid between water and amyl alcohol, when calculated at molar concentration for each of the solution, is:
- Drugs ‘A’, ‘B’ and ‘C’ follow zero order, first order and second order degradation kinetics, respectively, but have the same rate constant. Which of the following statement is true in this respect:
View More Questions