Question:
Chemical penetration enhancer used in Transdermal formulation
Chemical penetration enhancer used in Transdermal formulation
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DMSO: Dimethyl Sulfoxide—the "Door-opener" for skin penetration.
Updated On: May 25, 2026
- Chitin
- DMSO
- HPMC
- Polomex F64
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Concept
Transdermal Drug Delivery Systems (TDDS) often require enhancers to help drugs bypass the skin's primary barrier, the stratum corneum.
Step 2: Meaning
A chemical penetration enhancer reversibly decreases the barrier resistance of the skin.
Step 3: Analysis
HPMC is a polymer/binder. DMSO (Dimethyl sulfoxide) is a powerful solvent known for its ability to penetrate skin and carry other molecules with it.
Step 4: Conclusion
DMSO is a classic and potent chemical penetration enhancer. Final Answer: (B)
Transdermal Drug Delivery Systems (TDDS) often require enhancers to help drugs bypass the skin's primary barrier, the stratum corneum.
Step 2: Meaning
A chemical penetration enhancer reversibly decreases the barrier resistance of the skin.
Step 3: Analysis
HPMC is a polymer/binder. DMSO (Dimethyl sulfoxide) is a powerful solvent known for its ability to penetrate skin and carry other molecules with it.
Step 4: Conclusion
DMSO is a classic and potent chemical penetration enhancer. Final Answer: (B)
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