Question

Match List-I with List-II
{|l|l|} List-I (Condition) & List-II (Drug used)
(A). Cyanide Poisoning & (I). Calcium Disodium Edetate
(B). Lead poisoning & (II). Sodium Thiosulphate
(C). Trypanosomosis & (III). Isometamidium Chloride
(D). Hepatozoon canis infection & (IV). Imidocarb Dipropionate

Choose the correct answer from the options given below:

• (A) - (II), (B) - (I), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (III), (D) - (IV)
• (A) - (I), (B) - (II), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)

Hint:

In matching questions:
- Associate Lead poisoning with the chelator Calcium Disodium Edetate.
- Associate Cyanide poisoning with the sulfur-donor antidote Sodium Thiosulphate.
Knowing these two common toxicological antidotes immediately resolves the correct option.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Toxic poisonings and systemic protozoal infections in veterinary medicine require specific antidotes or targeted chemotherapeutic agents to neutralize toxins or eliminate pathogens.

Step 2: Detailed Explanation:
Let us match the conditions in List-I with the corresponding therapeutic drugs in List-II:
- (A) Cyanide Poisoning \(\rightarrow\) (II) Sodium Thiosulphate:
Sodium thiosulphate acts as an effective antidote for cyanide toxicosis.
It serves as a sulfur donor for the mitochondrial enzyme rhodanese.
This enzyme facilitates the conversion of highly toxic cyanide into non-toxic thiocyanate, which is excreted safely in urine.
- (B) Lead poisoning \(\rightarrow\) (I) Calcium Disodium Edetate:
Calcium Disodium Edetate (\(\text{CaNa}_2\text{EDTA}\)) is a heavy metal chelating agent.
It binds circulating divalent lead ions to form a stable, soluble, non-toxic complex that is readily excreted by the kidneys.
- (C) Trypanosomosis \(\rightarrow\) (III) Isometamidium Chloride:
Isometamidium chloride is a phenanthridinium-based trypanocide.
It is used for both the treatment and prophylaxis of animal trypanosomosis (caused by Trypanosa species, such as Surra).
- (D) Hepatozoon canis infection \(\rightarrow\) (IV) Imidocarb Dipropionate:
Imidocarb dipropionate is an antiprotozoal drug.
It is used to treat tick-borne intracellular protozoal infections, including canine babesiosis and hepatozoonosis.
This matches the sequence: (A)-(II), (B)-(I), (C)-(III), (D)-(IV), which corresponds to Option (A).

Step 3: Final Answer:
The correct matching is represented by Option (A).