Question

Match List-I with List-II.

\[ \begin{array}{|c|l|c|l|} \hline \textbf{List-I} & & \textbf{List-II} & \\ \hline A & \text{Thebaine} & I & \textit{Strophanthus gratus} \\ B & \text{d-Tubocurarine} & II & \text{Semi-synthetic Opioid} \\ C & \text{Ouabain} & III & \textit{Papaver somniferum} \\ D & \text{Etorphine} & IV & \textit{Chondrodendron tomentosum} \\ \hline \end{array} \] 
Choose the correct answer from the options given below:

• (A) - (II), (B) - (I), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (IV), (C) - (I), (D) - (II)
• (A) - (III), (B) - (I), (C) - (IV), (D) - (II)
• (A) - (II), (B) - (III), (C) - (IV), (D) - (I)

Hint:

Etorphine is so potent (approx. 10,000 times more potent than morphine) that it is exclusively used for wildlife immobilization (e.g., elephants) and requires an antagonist (diprenorphine or naltrexone) to be immediately available during handling.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
This matching question tests knowledge of pharmacologically active compounds, their primary natural plant sources, or their chemical classifications.
Detailed Explanation:
Let us match the drugs from List-I with their sources/classifications in List-II:
- (A) Thebaine: This is a natural opiate alkaloid obtained from the opium poppy, Papaver somniferum.
While it is not used directly in therapeutics due to its stimulant effects, it serves as a crucial raw material for synthesizing semi-synthetic opioids.
This matches with (III).
- (B) d-tubocurarine: This is a naturally occurring neuromuscular blocker extracted from the bark of Chondrodendron tomentosum, a South American vine historically used to make arrow poison (curare).
This matches with (IV).
- (C) Ouabain: Also known as g-strophanthin, this is a highly potent cardiac glycoside obtained from the seeds of Strophanthus gratus.
This matches with (I).
- (D) Etorphine: This is an extremely potent semi-synthetic opioid synthesized from thebaine, used in wildlife veterinary medicine for the immobilization of large mammals.
This matches with (II).
Combining these matches, we get: (A) - (III), (B) - (IV), (C) - (I), (D) - (II).

Step 2: Final Answer:
The correct matching sequence corresponds to option (B).