Question:
Given below are two statements:
Statement (I): The time of drug concentration above minimum inhibitory concentration ($T > \text{MIC}$) is important for clinical success in case of treatment with beta lactam antibiotics.
Statement (II): Carbapenems are sensitive to extended spectrum beta lactamases (ESBL).
In light of the above statements, choose the most appropriate answer from the options given below.
Given below are two statements:
Statement (I): The time of drug concentration above minimum inhibitory concentration ($T > \text{MIC}$) is important for clinical success in case of treatment with beta lactam antibiotics.
Statement (II): Carbapenems are sensitive to extended spectrum beta lactamases (ESBL).
In light of the above statements, choose the most appropriate answer from the options given below.
Statement (I): The time of drug concentration above minimum inhibitory concentration ($T > \text{MIC}$) is important for clinical success in case of treatment with beta lactam antibiotics.
Statement (II): Carbapenems are sensitive to extended spectrum beta lactamases (ESBL).
In light of the above statements, choose the most appropriate answer from the options given below.
Show Hint
Beta-lactams are time-dependent ($T > \text{MIC}$).
Aminoglycosides and Fluoroquinolones are concentration-dependent ($C_{\text{max}}/\text{MIC}$).
Carbapenems are highly stable against ESBLs.
Aminoglycosides and Fluoroquinolones are concentration-dependent ($C_{\text{max}}/\text{MIC}$).
Carbapenems are highly stable against ESBLs.
Updated On: Jul 14, 2026
- Both Statement (I) and Statement (II) are true.
- Both Statement (I) and Statement (II) are false.
- Statement (I) is true but Statement (II) is false.
- Statement (I) is false but Statement (II) is true.
Show Solution
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The Correct Option is C
Solution and Explanation
Step 1: Understanding the Concept:
This question tests pharmacodynamic principles of antibiotics (time-dependent vs. concentration-dependent) and mechanisms of beta-lactamase resistance.
Detailed Explanation:
- Statement (I) Evaluation: Beta-lactam antibiotics (penicillins, cephalosporins) are time-dependent bactericidal agents.
Their clinical efficacy is determined by the percentage of time during the dosing interval that the free drug concentration remains above the minimum inhibitory concentration ($T > \text{MIC}$).
Increasing the peak concentration far above the MIC does not increase their killing rate. Thus, Statement (I) is correct.
- Statement (II) Evaluation: Carbapenems (e.g., imipenem, meropenem) are a unique class of beta-lactam antibiotics.
They possess a trans-alpha-hydroxyethyl group at position 6, which provides high stability and resistance against hydrolysis by extended-spectrum beta-lactamases (ESBLs).
Carbapenems are typically the drug of choice for treating infections caused by ESBL-producing bacteria.
Therefore, they are not sensitive to ESBLs, making Statement (II) incorrect.
Step 2: Final Answer:
Statement (I) is true but Statement (II) is false. This corresponds to option (C).
This question tests pharmacodynamic principles of antibiotics (time-dependent vs. concentration-dependent) and mechanisms of beta-lactamase resistance.
Detailed Explanation:
- Statement (I) Evaluation: Beta-lactam antibiotics (penicillins, cephalosporins) are time-dependent bactericidal agents.
Their clinical efficacy is determined by the percentage of time during the dosing interval that the free drug concentration remains above the minimum inhibitory concentration ($T > \text{MIC}$).
Increasing the peak concentration far above the MIC does not increase their killing rate. Thus, Statement (I) is correct.
- Statement (II) Evaluation: Carbapenems (e.g., imipenem, meropenem) are a unique class of beta-lactam antibiotics.
They possess a trans-alpha-hydroxyethyl group at position 6, which provides high stability and resistance against hydrolysis by extended-spectrum beta-lactamases (ESBLs).
Carbapenems are typically the drug of choice for treating infections caused by ESBL-producing bacteria.
Therefore, they are not sensitive to ESBLs, making Statement (II) incorrect.
Step 2: Final Answer:
Statement (I) is true but Statement (II) is false. This corresponds to option (C).
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