Question

Arrange the adverse effects of Chloramphenicol, Tetracyclines, Aminoglycosides and Sulfadiazine in correct order
(A). Keratoconjunctivitis sicca
(B). Teeth discoloration
(C). Ashen-gray skin discoloration
(D). Deafness
Choose the correct answer from the options given below:

• A. (C), (D), (A), (B)
• B. (C), (B), (D), (A)
• C. (B), (C), (A), (D)
• D. (B), (D), (C), (A)

Hint:

Remember these high-yield associations:
Sulfonamides in dogs $\rightarrow$ Dry Eye (KCS)
Tetracyclines in young/pregnant animals $\rightarrow$ Yellow teeth
Aminoglycosides $\rightarrow$ Ototoxicity (Deafness)

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
This question requires matching specific, well-known adverse drug reactions to their corresponding antimicrobial classes and ordering them as presented in the question stem: Chloramphenicol, Tetracyclines, Aminoglycosides, and Sulfadiazine.
Detailed Explanation:
Let us identify the classic adverse effect of each drug:
1. Chloramphenicol: In neonates (who lack mature hepatic glucuronyl transferase enzymes), high levels of chloramphenicol can cause cardiovascular collapse and a distinct ashen-gray skin discoloration, known as the "Gray Baby Syndrome."
This matches with (C).
2. Tetracyclines: These drugs have a strong chelating affinity for calcium ions.
If administered during pregnancy or early development, they deposit in active calcification sites of developing teeth, leading to permanent yellow-brown teeth discoloration.
This matches with (B).
3. Aminoglycosides: These drugs are highly ototoxic and can damage the sensory hair cells of the cochlea, leading to irreversible hearing loss and deafness.
This matches with (D).
4. Sulfadiazine: Sulfonamides, particularly sulfadiazine, are toxic to the lacrimal glands in dogs, leading to a reduction in tear production and the development of dry eye, clinically known as Keratoconjunctivitis sicca.
This matches with (A).
Arranging these in the order of the drugs listed (Chloramphenicol $\rightarrow$ Tetracyclines $\rightarrow$ Aminoglycosides $\rightarrow$ Sulfadiazine) gives: (C) $\rightarrow$ (B) $\rightarrow$ (D) $\rightarrow$ (A).

Step 2: Final Answer:
This sequence corresponds to option (B).