Question

Match List-I with List-II.

\[ \begin{array}{|c|l|c|l|} \hline \textbf{List-I} & & \textbf{List-II} & \\ \hline A & \text{Triorthocresyl Phosphate (TOCP)} & I & \text{Pulmonary Fibrosis} \\ B & \text{Paraquat} & II & \text{Severe Hyperthermia} \\ C & \text{Deltamethrin} & III & \text{Delayed Neurotoxicity} \\ D & \text{Dinitrophenol} & IV & \text{CS Syndrome} \\ \hline \end{array} \] 
Choose the correct answer from the options given below:

• (A) - (II), (B) - (III), (C) - (IV), (D) - (I)
• (A) - (II), (B) - (I), (C) - (IV), (D) - (III)
• (A) - (III), (B) - (I), (C) - (IV), (D) - (II)
• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)

Hint:

Remember:
Type I Pyrethroids $\rightarrow$ T-Syndrome (Tremors)
Type II Pyrethroids (e.g., Deltamethrin) $\rightarrow$ CS-Syndrome (Choreoathetosis/Salivation)
Paraquat toxicity uniquely targets the lung tissue.

Answer 1

The Correct Option is C

Step 1: Understanding the Concept:
This matching task involves associating specific agrochemicals or environmental toxins with their characteristic physiological toxicities or syndromes.
Detailed Explanation:
Let us analyze the toxic effects of each substance:
- (A) Triorthocresyl phosphate (TOCP): This is an organophosphorus ester.
Unlike typical insecticides, it exhibits weak anticholinesterase activity but is notorious for inducing Organophosphorus-Induced Delayed Neuropathy (OPIDN).
This delayed neurotoxicity manifests as progressive flaccid paralysis of distal limbs 1 to 3 weeks after exposure.
This matches with (III).
- (B) Paraquat: This is a bipyridilium herbicide.
It selectively accumulates in the alveolar epithelial cells of the lungs via active transport.
Inside the cells, it undergoes redox cycling, generating abundant reactive oxygen species (ROS) that cause irreversible, progressive pulmonary fibrosis.
This matches with (I).
- (C) Deltamethrin: This is a Type II pyrethroid insecticide containing an $\alpha$-cyano group.
Type II pyrethroids cause prolonged depolarization of the sodium channel membrane, resulting in choreoathetosis (involuntary writhing movements) and salivation, collectively known as the CS syndrome.
This matches with (IV).
- (D) Dinitrophenol: This is a mitochondrial uncoupler of oxidative phosphorylation.
It dissipates the proton gradient across the inner mitochondrial membrane, preventing ATP synthesis.
As a result, metabolic energy is lost entirely as heat, causing severe, often fatal, hyperthermia.
This matches with (II).
Combining these matches, we get: (A) - (III), (B) - (I), (C) - (IV), (D) - (II).

Step 2: Final Answer:
The matching sequence corresponds to option (C).