Question

Match List-I with List-II.

\[ \begin{array}{|c|l|c|l|} \hline \textbf{List-I} & & \textbf{List-II} & \\ \hline A & \textit{Schistosoma} \text{ sp.} & I & \text{Butynurate} \\ B & \textit{Fasciola gigantica} & II & \text{Praziquantel} \\ C & \text{Poultry Cestodes} & III & \text{Ivermectin} \\ D & \textit{Dictyocaulus filaria} & IV & \text{Triclabendazole} \\ \hline \end{array} \] 
Choose the correct answer from the options given below:

• (A) - (III), (B) - (II), (C) - (I), (D) - (IV)
• (A) - (II), (B) - (IV), (C) - (I), (D) - (III)
• (A) - (III), (B) - (II), (C) - (IV), (D) - (I)
• (A) - (IV), (B) - (II), (C) - (III), (D) - (I)

Hint:

Remember that Triclabendazole is the only benzimidazole compound effective against the highly pathogenic, young migrating stages of *Fasciola*.
Praziquantel is the drug of choice for treating cestodes and schistosomes.

Answer 1

The Correct Option is B

Step 1: Understanding the Concept:
This matching question requires associating different classes of parasites with their highly effective, drug-of-choice anthelmintic treatments.
Detailed Explanation:
Let us match each parasite from List-I with its corresponding treatment in List-II:
(A) Schistosoma sp. (Blood flukes):
Praziquantel is highly effective against both adult and immature schistosomes.
It alters the calcium permeability of the parasite's membrane, causing severe muscle contractions and tegumental damage.
Thus, (A) matches with (II).
(B) Fasciola gigantica (Giant liver fluke):
Triclabendazole is a unique benzimidazole flukicide that has exceptional efficacy against both adult and immature (migratory) liver flukes.
Thus, (B) matches with (IV).
(C) Poultry cestodes (Tapeworms):
Butynurate (Dibutyltin dilaurate) is an organotin compound that has historically been used in poultry flock medicine for the treatment of tapeworms.
Thus, (C) matches with (I).
(D) Dictyocaulus filaria (Sheep lungworm):
Ivermectin is a macrocyclic lactone with broad-spectrum activity against roundworms, including lungworms residing in the bronchial tree.
Thus, (D) matches with (III).
Combining these matches, we get: (A) - (II), (B) - (IV), (C) - (I), (D) - (III).

Step 2: Final Answer:
The matched sequence corresponds to option (B).