Question:
The conversion of acyclovir to its active nucleotide form by viral thymidine kinase involves which type of reaction
The conversion of acyclovir to its active nucleotide form by viral thymidine kinase involves which type of reaction
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Acyclovir needs 3 phosphates (Triphosphate) to "tri" and stop viral DNA.
Updated On: May 25, 2026
- Acyclovir thymidine trihydroxy phosphate, phosphorylation
- Acyclovir thymidine hydroxy phosphate, phosphorylation
- Acyclovir phosphate, hydroxylation
- Acyclovir diphosphate, hydroxylation
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Acyclovir is a guanosine analogue prodrug used to treat viral infections like Herpes Simplex.
Step 2: Meaning
A prodrug must be chemically transformed within the body—in this case, by viral enzymes—to become pharmacologically active.
Step 3: Analysis
Viral thymidine kinase converts acyclovir to acyclovir monophosphate. Subsequently, host cell enzymes convert it into the active triphosphate form. This addition of phosphate groups is known as phosphorylation.
Step 4: Conclusion
The process described in the diagram involves the sequential phosphorylation to the active triphosphate state. Final Answer: (A)
Acyclovir is a guanosine analogue prodrug used to treat viral infections like Herpes Simplex.
Step 2: Meaning
A prodrug must be chemically transformed within the body—in this case, by viral enzymes—to become pharmacologically active.
Step 3: Analysis
Viral thymidine kinase converts acyclovir to acyclovir monophosphate. Subsequently, host cell enzymes convert it into the active triphosphate form. This addition of phosphate groups is known as phosphorylation.
Step 4: Conclusion
The process described in the diagram involves the sequential phosphorylation to the active triphosphate state. Final Answer: (A)
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