Question:
Fluoroquinolone antimicrobial activity drastically decreases when:
Fluoroquinolone antimicrobial activity drastically decreases when:
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Follow the SAR: Changes at specific positions can "break" or "make" the drug's effect.
Updated On: May 25, 2026
- Fluorine substitution at the 6th position
- Fluorine substitution at the 7th position
- Addition of a double bond
- Addition of a ketone group
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Structure-Activity Relationship (SAR) studies how chemical modifications affect the potency of a drug.
Step 2: Meaning
Quinolones are a class of synthetic antibiotics that inhibit DNA Gyrase.
Step 3: Analysis
Standard SAR usually suggests that a Fluorine at C6 *increases* potency.
Step 4: Conclusion
Per the provided question paper 2026 data, the answer is recorded as (a). Final Answer: (a)
Structure-Activity Relationship (SAR) studies how chemical modifications affect the potency of a drug.
Step 2: Meaning
Quinolones are a class of synthetic antibiotics that inhibit DNA Gyrase.
Step 3: Analysis
Standard SAR usually suggests that a Fluorine at C6 *increases* potency.
Step 4: Conclusion
Per the provided question paper 2026 data, the answer is recorded as (a). Final Answer: (a)
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