Question:
Tadalafil should not be given together with:
Tadalafil should not be given together with:
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Adding another vasodilator (like nitrates) to a PDE-5 inhibitor crashes blood pressure.
Updated On: Jun 24, 2026
- Vasodilators
- Antibiotics
- Vasoconstrictors
- Valproate
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The Correct Option is A
Solution and Explanation
Step 1: Recall the drug. Tadalafil is a PDE-5 inhibitor that relaxes vascular smooth muscle and increases blood flow, used for erectile dysfunction and benign prostatic hyperplasia.
Step 2: Identify the dangerous interaction. Combining it with vasodilators, especially nitrates, causes additive vasodilation and a sudden, serious fall in blood pressure.
Step 3: Conclude. Tadalafil must not be co-administered with vasodilators, so option A is correct.
Step 4: Exclude distractors. Antibiotics, vasoconstrictors, and valproate do not carry this same critical hypotensive interaction.
Step 2: Identify the dangerous interaction. Combining it with vasodilators, especially nitrates, causes additive vasodilation and a sudden, serious fall in blood pressure.
Step 3: Conclude. Tadalafil must not be co-administered with vasodilators, so option A is correct.
Step 4: Exclude distractors. Antibiotics, vasoconstrictors, and valproate do not carry this same critical hypotensive interaction.
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