Question

A 58-year-old patient has prolonged PT and factor IX deficiency. Parenteral vitamin K is planned. In which condition will this help?

• A. Hepatitis A
• B. Pernicious anemia
• C. Hemophilia B
• D. Bile duct obstruction

Hint:

Vitamin K deficiency can occur in bile duct obstruction because vitamin K is fat-soluble and needs bile for absorption.

Answer 1

The Correct Option is D

Concept: Vitamin K is fat-soluble and requires bile for absorption. Bile duct obstruction can cause vitamin K deficiency, leading to prolonged PT due to reduced vitamin K-dependent clotting factors.

Step 1: Recall vitamin K-dependent factors.
Vitamin K is needed for synthesis of: \[ II,\ VII,\ IX,\ X,\ Protein\ C,\ Protein\ S \]

Step 2: Identify condition causing deficiency.
Bile duct obstruction reduces bile flow into the intestine. This impairs absorption of fat-soluble vitamins, including vitamin K.

Step 3: Choose condition where vitamin K helps.
Therefore, parenteral vitamin K will help in: \[ \text{Bile duct obstruction} \]