Question:

A 35-year-old woman is diagnosed with migraine and has a family history of coronary artery disease. She has been previously treated with sumatriptan. What is the drug of choice for migraine prophylaxis?

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Migraine acute attack = triptans; migraine prophylaxis = propranolol, topiramate, valproate, etc.
Updated On: Aug 27, 2026
  • Propranolol
  • Topiramate
  • Ergotamine
  • Naratriptan
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The Correct Option is A

Solution and Explanation

Concept: Migraine prophylaxis is used when attacks are frequent or disabling. Beta blockers such as propranolol are commonly used for migraine prevention.

Step 1:
Differentiate acute treatment and prophylaxis.
Sumatriptan is used for acute migraine attacks. Prophylaxis requires drugs such as beta blockers, topiramate, or valproate.

Step 2:
Identify the best option.
Among the given options, propranolol is a standard migraine prophylactic drug.

Step 3:
Avoid acute-only drugs.
Ergotamine and naratriptan are mainly used for acute migraine treatment, not routine prophylaxis. Therefore, the correct answer is Propranolol.
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