Question:
A child presents with gum bleeding, perifollicular hemorrhages, petechiae, and recurrent fractures. Which enzyme deficiency is most likely?
A child presents with gum bleeding, perifollicular hemorrhages, petechiae, and recurrent fractures. Which enzyme deficiency is most likely?
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Vitamin C deficiency impairs collagen synthesis by reducing hydroxylation of proline and lysine.
Updated On: May 14, 2026
- Lysyl oxidase
- Prolyl hydroxylase
- Tyrosinase
- Alkaline phosphatase
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The Correct Option is B
Solution and Explanation
Concept:
Gum bleeding, perifollicular hemorrhage and bone fragility suggest vitamin C deficiency. Vitamin C is required for hydroxylation of proline and lysine during collagen synthesis.
Step 1: Identify clinical syndrome.
The symptoms suggest: \[ \text{Scurvy} \] which is due to vitamin C deficiency.
Step 2: Recall enzyme affected.
Vitamin C is a cofactor for: \[ \text{Prolyl hydroxylase} \] and lysyl hydroxylase.
Step 3: Choose the best option.
Among the options, the most likely enzyme deficiency is: \[ \text{Prolyl hydroxylase} \]
Step 1: Identify clinical syndrome.
The symptoms suggest: \[ \text{Scurvy} \] which is due to vitamin C deficiency.
Step 2: Recall enzyme affected.
Vitamin C is a cofactor for: \[ \text{Prolyl hydroxylase} \] and lysyl hydroxylase.
Step 3: Choose the best option.
Among the options, the most likely enzyme deficiency is: \[ \text{Prolyl hydroxylase} \]
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