Question:
Patients administered sevoflurane and succinylcholine for abdominal surgery develops post-operative muscle rigidity. What is the drug of choice here?
Patients administered sevoflurane and succinylcholine for abdominal surgery develops post-operative muscle rigidity. What is the drug of choice here?
Show Hint
Malignant hyperthermia after succinylcholine or volatile anesthetics is treated with dantrolene.
Updated On: May 14, 2026
- Dantrolene
- Diazepam
- Propranolol
- Paracetamol
Show Solution
Verified By Collegedunia
The Correct Option is A
Solution and Explanation
Concept:
Sevoflurane and succinylcholine can trigger malignant hyperthermia in susceptible individuals. It presents with muscle rigidity, hyperthermia, acidosis and hyperkalemia.
Step 1: Identify the condition.
The patient develops muscle rigidity after exposure to: \[ \text{Volatile anesthetic + succinylcholine} \] This suggests malignant hyperthermia.
Step 2: Recall drug of choice.
The drug of choice for malignant hyperthermia is: \[ \text{Dantrolene} \]
Step 3: Mechanism of action.
Dantrolene acts on ryanodine receptors and reduces calcium release from sarcoplasmic reticulum.
Step 1: Identify the condition.
The patient develops muscle rigidity after exposure to: \[ \text{Volatile anesthetic + succinylcholine} \] This suggests malignant hyperthermia.
Step 2: Recall drug of choice.
The drug of choice for malignant hyperthermia is: \[ \text{Dantrolene} \]
Step 3: Mechanism of action.
Dantrolene acts on ryanodine receptors and reduces calcium release from sarcoplasmic reticulum.
Was this answer helpful?
0
0
Top NEET PG Pharmacology Questions
- A bronchial asthma patient on inhalational steroids presented with white patchy lesions on the tongue and buccal mucosa. What is the drug that can be used to treat this condition?
- A pregnant woman with a history of bronchial asthma is in the third stage of labor. Which drugs should be avoided in managing postpartum hemorrhage in this mother?
- Name the drug that acts on both the marked areas.
- A patient with a previous history of myocardial infarction and ventricular arrhythmia is ontreatment for a few months. He developed fatigue, dyspnea, and weight gain. He had also developed pulmonary fibrosis. Which of the following drugs is responsible for the side effects mentioned above?
- A young female comes to the emergency department after consuming 100 aspirin tablets.What should be the next step in management?
View More Questions
Top NEET PG Pharmacology of central nervous System Questions
- A patient comes to the casualty with organophosphate poisoning. He was started on atropine infusion and pralidoxime. After 2 hours, the patient had a sudden rise in temperature. What is the likely cause of fever?
- A patient was administered a muscle relaxant and subsequently developed erythema, facial flushing, and hypotension. Which drug is most likely responsible for these symptoms?
- A patient already on salbutamol and ipratropium continues to have nocturnal exacerbations of asthma. What is the next step?
- A 60-year-old man with ischemic cardiomyopathy and palpitations is started on amiodarone. Which phase of the cardiac action potential is its primary site of action?
- A 35-year-old woman is diagnosed with migraine and has a family history of coronary artery disease. She has been previously treated with sumatriptan. What is the drug of choice for migraine prophylaxis?
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions