Question:
Which of the following, if given in large volumes, can lead to hyperchloremic metabolic acidosis?
Which of the following, if given in large volumes, can lead to hyperchloremic metabolic acidosis?
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Large-volume normal saline can cause hyperchloremic metabolic acidosis due to excess chloride load.
Updated On: Aug 27, 2026
- Dextrose in NS (DNS)
- Normal saline (NS)
- 5% dextrose in water
- Ringer lactate
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The Correct Option is B
Solution and Explanation
Concept:
Large-volume administration of normal saline can cause hyperchloremic metabolic acidosis because normal saline contains a high chloride concentration.
Step 1: Identify the fluid.
Normal saline contains: \[ Na^+ = 154 \text{ mEq/L}, \quad Cl^- = 154 \text{ mEq/L} \]
Step 2: Understand the mechanism.
Excess chloride reduces bicarbonate concentration and produces a normal anion gap metabolic acidosis.
Step 3: Select the correct option.
The fluid most associated with hyperchloremic metabolic acidosis is: \[ \text{Normal saline} \] Therefore, the correct answer is Normal saline (NS).
Step 1: Identify the fluid.
Normal saline contains: \[ Na^+ = 154 \text{ mEq/L}, \quad Cl^- = 154 \text{ mEq/L} \]
Step 2: Understand the mechanism.
Excess chloride reduces bicarbonate concentration and produces a normal anion gap metabolic acidosis.
Step 3: Select the correct option.
The fluid most associated with hyperchloremic metabolic acidosis is: \[ \text{Normal saline} \] Therefore, the correct answer is Normal saline (NS).
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