Question:
Tadalafil should NOT be given together with which of the following?
Tadalafil should NOT be given together with which of the following?
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Two blood-pressure-lowering drugs together can crash the pressure dangerously.
Updated On: Jun 23, 2026
- Vasodilator
- Antibiotics
- Vasoconstrictors
- Valproate
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The Correct Option is A
Solution and Explanation
Step 1: Recall the drug action. Tadalafil is a phosphodiesterase-5 inhibitor that relaxes vascular smooth muscle and increases blood flow, used for erectile dysfunction and benign prostatic hypertrophy.
Step 2: Identify the dangerous interaction. Because tadalafil already lowers vascular tone, combining it with another vasodilator (especially nitrates) produces additive vasodilation and a sudden, serious drop in blood pressure.
Step 3: Choose the answer. Option a, a vasodilator, is contraindicated with tadalafil.
Step 4: Exclude the rest. Vasoconstrictors would oppose, not add to, its effect; antibiotics and valproate do not share this hemodynamic synergy and are not the classic contraindication.
Step 2: Identify the dangerous interaction. Because tadalafil already lowers vascular tone, combining it with another vasodilator (especially nitrates) produces additive vasodilation and a sudden, serious drop in blood pressure.
Step 3: Choose the answer. Option a, a vasodilator, is contraindicated with tadalafil.
Step 4: Exclude the rest. Vasoconstrictors would oppose, not add to, its effect; antibiotics and valproate do not share this hemodynamic synergy and are not the classic contraindication.
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