Question:
According to the IP, the standardization of Vitamin \(B_{12}\) is done using a microbial assay. The test organism used is:
According to the IP, the standardization of Vitamin \(B_{12}\) is done using a microbial assay. The test organism used is:
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$B_{12}$ = Leichmannii (Remember: 12 is "L" in roman? No, but L for Leichmannii).
Updated On: May 25, 2026
- Streptococcus faecalis
- Leuconostoc mesenteroides
- Lactobacillus leichmannii
- Lactobacillus plantarum
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The Correct Option is C
Solution and Explanation
Step 1: Concept
Microbiological assays are used to determine the potency of vitamins or antibiotics by measuring the growth response of specific microorganisms.
Step 2: Meaning
A test organism is selected because its growth is specifically dependent on the presence of the substance being assayed.
Step 3: Analysis
For Cyanocobalamin (Vitamin $B_{12}$), the Indian Pharmacopoeia (IP) specifies the use of Lactobacillus leichmannii (also known as Lactobacillus delbrueckii subsp. lactis).
Step 4: Conclusion
The correct test organism for Vitamin $B_{12}$ is Lactobacillus leichmannii. Final Answer: (C)
Microbiological assays are used to determine the potency of vitamins or antibiotics by measuring the growth response of specific microorganisms.
Step 2: Meaning
A test organism is selected because its growth is specifically dependent on the presence of the substance being assayed.
Step 3: Analysis
For Cyanocobalamin (Vitamin $B_{12}$), the Indian Pharmacopoeia (IP) specifies the use of Lactobacillus leichmannii (also known as Lactobacillus delbrueckii subsp. lactis).
Step 4: Conclusion
The correct test organism for Vitamin $B_{12}$ is Lactobacillus leichmannii. Final Answer: (C)
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