Question:
Which of the following is not a prokinetic agent?
Which of the following is not a prokinetic agent?
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One of these is actually a stimulant laxative group, not a gut motility enhancer.
Updated On: Jun 23, 2026
- Dopamine antagonist
- 5-HT4 agonist
- Macrolides
- Diphenylmethane
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The Correct Option is D
Solution and Explanation
Step 1: Prokinetics promote gastrointestinal transit and speed gastric emptying by enhancing coordinated propulsive motility. They differ from older cholinomimetics, which cause tonic, uncoordinated contractions.
Step 2: Dopamine (D2) antagonists like metoclopramide and domperidone are prokinetic. 5-HT4 agonists like cisapride and mosapride are prokinetic. Macrolides such as erythromycin act as motilin receptor agonists and are used as prokinetics.
Step 3: Diphenylmethane refers to the stimulant laxative group (bisacodyl, phenolphthalein). These act on the colonic mucosa as laxatives, not as prokinetics. So diphenylmethane is not a prokinetic agent.
Ref: K. D. Tripathi, 7th Edition, Pages 663-665.
Step 2: Dopamine (D2) antagonists like metoclopramide and domperidone are prokinetic. 5-HT4 agonists like cisapride and mosapride are prokinetic. Macrolides such as erythromycin act as motilin receptor agonists and are used as prokinetics.
Step 3: Diphenylmethane refers to the stimulant laxative group (bisacodyl, phenolphthalein). These act on the colonic mucosa as laxatives, not as prokinetics. So diphenylmethane is not a prokinetic agent.
Ref: K. D. Tripathi, 7th Edition, Pages 663-665.
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