Question:
Which of the following antibody is used by immune complexes for complement activation?
Which of the following antibody is used by immune complexes for complement activation?
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• Complement activation → IgM $>$ IgG
• IgM is most efficient due to pentamer form
Updated On: May 13, 2026
- IgA
- IgM
- IgE
- IgD
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The Correct Option is B
Solution and Explanation
Concept:
Complement activation via the classical pathway is triggered by antigen–antibody complexes.
• IgM and IgG can activate complement
• IgM is most efficient due to its pentameric structure
Step 1: Analyzing each option.
• IgA: Does not activate complement effectively → Incorrect.
• IgM: Strong activator of complement → Correct.
• IgE: Involved in allergy → Incorrect.
• IgD: Role mainly in B-cell activation → Incorrect.
Step 2: Selecting the correct answer.
Thus, IgM is used for complement activation.
• IgM and IgG can activate complement
• IgM is most efficient due to its pentameric structure
Step 1: Analyzing each option.
• IgA: Does not activate complement effectively → Incorrect.
• IgM: Strong activator of complement → Correct.
• IgE: Involved in allergy → Incorrect.
• IgD: Role mainly in B-cell activation → Incorrect.
Step 2: Selecting the correct answer.
Thus, IgM is used for complement activation.
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