Question

The selection of cells whose T-cell receptors respond to self-MHC is known as:

• A. Negative selection
• B. MHC restriction
• C. Affinity maturation
• D. Lineage commitment

Hint:

MHC Restriction: T-cells only "talk" to antigens presented on the "home team" MHC.

Answer 1

The Correct Option is B

Step 1: Concept
T-cells develop in the thymus, where they undergo rigorous screening processes.

Step 2: Meaning
Positive selection ensures that only T-cells capable of recognizing the body's own MHC molecules survive.

Step 3: Analysis
This process results in "MHC restriction," where a T-cell will only respond to an antigen if it is presented by a specific MHC molecule that the T-cell "learned" to recognize during development. Negative selection, by contrast, eliminates T-cells that bind *too* strongly to self-antigens.

Step 4: Conclusion
The ability and requirement to respond to self-MHC is termed MHC restriction. Final Answer: (B)