Question:
Which antibody is involved in Type I hypersensitivity reaction?
Which antibody is involved in Type I hypersensitivity reaction?
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• Type I hypersensitivity = IgE mediated
• Example: Allergy, asthma
Updated On: May 13, 2026
- IgM
- IgG
- IgE
- IgA
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The Correct Option is C
Solution and Explanation
Concept:
Type I hypersensitivity is also known as immediate hypersensitivity or allergic reaction.
• Mediated by IgE antibodies
• Involves mast cells and basophils
• Leads to release of histamine and other mediators
Step 1: Understanding mechanism.
• IgE binds to allergens and attaches to mast cells
• Upon re-exposure → degranulation → allergic response
Step 2: Analyzing options.
• IgM: Primary immune response → Incorrect.
• IgG: Secondary immune response → Incorrect.
• IgE: Mediates allergic reactions → Correct.
• IgA: Mucosal immunity → Incorrect.
Step 3: Selecting the correct answer.
Thus, IgE is responsible for Type I hypersensitivity.
• Mediated by IgE antibodies
• Involves mast cells and basophils
• Leads to release of histamine and other mediators
Step 1: Understanding mechanism.
• IgE binds to allergens and attaches to mast cells
• Upon re-exposure → degranulation → allergic response
Step 2: Analyzing options.
• IgM: Primary immune response → Incorrect.
• IgG: Secondary immune response → Incorrect.
• IgE: Mediates allergic reactions → Correct.
• IgA: Mucosal immunity → Incorrect.
Step 3: Selecting the correct answer.
Thus, IgE is responsible for Type I hypersensitivity.
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