Question

The deficiency of which vitamin in the body causes Pernicious Anaemia?

• A. Vitamin $B_6$
• B. Vitamin $B_1$
• C. Vitamin $B_{12}$
• D. Vitamin $B_2$

Hint:

- Vitamin $B_{12}$ deficiency → Pernicious anaemia - Iron deficiency → General anaemia - Vitamin $B_1$ deficiency → Beriberi

Answer 1

The Correct Option is C

Concept: Pernicious anaemia is a type of megaloblastic anaemia caused due to deficiency of Vitamin $B_{12$}. This vitamin is essential for red blood cell formation and proper functioning of the nervous system.

Step 1: Role of Vitamin $B_{12}$.

• Helps in DNA synthesis
• Essential for maturation of red blood cells

Step 2: Effect of deficiency.
Deficiency leads to:
• Formation of large, immature RBCs
• Reduced oxygen-carrying capacity
• Symptoms of anaemia

Step 3: Analyze options.

• $B_6$ → Pyridoxine (amino acid metabolism)
• $B_1$ → Thiamine (beriberi)
• $B_{12}$ → Causes pernicious anaemia (correct)
• $B_2$ → Riboflavin (energy metabolism)

Step 4: Final conclusion.
Thus, the deficiency responsible is: \[ Vitamin B_{12} \]