Question:
Based on the phosphoryl transfer potential, identify which one of the following cannot help in the generation of ATP from ADP?
Based on the phosphoryl transfer potential, identify which one of the following cannot help in the generation of ATP from ADP?
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High-energy "donors" (PEP, 1,3-BPG) sit above ATP on the energy ladder. Glucose-1-P sits below it.
Updated On: May 14, 2026
- Glucose-1-phosphate
- Creatine phosphate
- 1,3-bis-phosphoglycerate
- Phosphoenol pyruvate
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The Correct Option is A
Solution and Explanation
Step 1: Concept
To transfer a phosphate group to ADP to form ATP, a molecule must have a higher (more negative) phosphoryl transfer potential than ATP.
Step 2: Analysis of High-Energy Compounds
Phosphoenol pyruvate, 1,3-BPG, and Creatine phosphate all have higher potentials than ATP, allowing for substrate-level phosphorylation.
Step 3: Reasoning
Glucose-1-phosphate has a lower phosphoryl transfer potential than ATP. Therefore, it cannot spontaneously donate a phosphate to ADP to synthesize ATP.
Step 4: Conclusion
Glucose-1-phosphate cannot help in the generation of ATP. Final Answer: (A)
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