Question:
Proportionality of DNA-Nucleotide base pairing is observed by
Proportionality of DNA-Nucleotide base pairing is observed by
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Chargaff's rule (A=T, G=C) laid the foundation for Watson and Crick's double helix model of DNA.
Updated On: Jun 19, 2026
- Griffith
- Erwin Chargaff
- Hercules
- Watson
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The Correct Option is B
Solution and Explanation
Step 1: Understanding DNA structure.
DNA is composed of four nucleotide bases: Adenine (A), Thymine (T), Guanine (G), and Cytosine (C).
Step 2: Chargaff's contribution.
- Erwin Chargaff observed that in any DNA molecule:
\[ \text{A = T and G = C} \] - This rule is called Chargaff's rule.
Step 3: Significance.
- Proportionality of base pairing was critical in understanding the double helix structure of DNA.
- It implied that purines (A, G) pair with pyrimidines (T, C) in a 1:1 ratio.
Step 4: Experiments by others.
- Griffith: transformation experiments with bacteria, unrelated to base pairing.
- Hercules: not associated with DNA research.
- Watson: co-discovered DNA structure, used Chargaff's data.
Step 5: Conclusion.
Therefore, the proportionality of DNA-nucleotide base pairing was observed by Erwin Chargaff.
DNA is composed of four nucleotide bases: Adenine (A), Thymine (T), Guanine (G), and Cytosine (C).
Step 2: Chargaff's contribution.
- Erwin Chargaff observed that in any DNA molecule:
\[ \text{A = T and G = C} \] - This rule is called Chargaff's rule.
Step 3: Significance.
- Proportionality of base pairing was critical in understanding the double helix structure of DNA.
- It implied that purines (A, G) pair with pyrimidines (T, C) in a 1:1 ratio.
Step 4: Experiments by others.
- Griffith: transformation experiments with bacteria, unrelated to base pairing.
- Hercules: not associated with DNA research.
- Watson: co-discovered DNA structure, used Chargaff's data.
Step 5: Conclusion.
Therefore, the proportionality of DNA-nucleotide base pairing was observed by Erwin Chargaff.
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