Question

Based on the below representation of Central Dogma – Genetic information flows from Replication:

• A. Transcription, t-RNA, RNA, Translation
• B. Transcription, r-RNA, RNA, Translation
• C. Transcription, m-RNA, Translation, Protein
• D. Primer, hn-RNA, Transcription, Aminoacid

Hint:

Central Dogma: DNA → m-RNA (Transcription) → Protein (Translation). t-RNA and r-RNA assist translation but are not intermediates carrying the code.

Answer 1

The Correct Option is C

Step 1: Understand the Central Dogma.
Central Dogma of molecular biology describes the flow of genetic information: DNA → RNA → Protein.

Step 2: Identify the processes.
- Transcription: DNA is used as a template to synthesize messenger RNA (m-RNA).
- Translation: m-RNA is used as a template to synthesize polypeptides (proteins).

Step 3: Role of intermediates.
- m-RNA carries the genetic code from DNA to ribosomes.
- t-RNA and r-RNA are functional RNA molecules aiding translation, not directly coded from the DNA sequence itself.

Step 4: Sequence representation.
-
Step 1: DNA →
Step 2: Transcription →
Step 3: m-RNA →
Step 4: Translation → Protein

Step 5: Exclude other options.
- Options mentioning t-RNA or r-RNA in the main flow misrepresent the sequence.
- Primer or hn-RNA is not part of the main genetic information flow.

Step 6: Conclusion.
Hence, the correct sequence in Central Dogma is: Transcription, m-RNA, Translation, Protein.