Question:
One of the limitations of Y-chromosome DNA profiling is that
One of the limitations of Y-chromosome DNA profiling is that
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Y-DNA = Paternal lineage. It stays the same across generations of men in a family.
Updated On: May 14, 2026
- genetic variability on Y-chromosome is much more than that on autosomes.
- it cannot differentiate between DNA from father, son and male siblings.
- Y-chromosome has high recombination frequency.
- it is difficult to PCR amplify Y-chromosome STRs.
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The Correct Option is B
Solution and Explanation
Step 1: Concept
The Y-chromosome is passed almost entirely intact from father to son.
Step 2: Meaning
Unlike autosomes, the majority of the Y-chromosome does not undergo recombination.
Step 3: Analysis
Because there is no recombination to shuffle the alleles, all males in the same paternal lineage (grandfather, father, son, brothers) will share the same Y-STR profile.
Step 4: Conclusion
Consequently, Y-profiling cannot distinguish between closely related males in a paternal line. Final Answer: (B)
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