Question

Match items in List I with items in List II
List I: A. Silent mutation, B. Missense mutation, C. Nonsense mutation, D. Frameshift mutation
List II: I. Amino acid codon changed to stop codon, II. Sequence beyond mutation changed, III. Sequence changed in one amino acid, IV. Amino acid sequence is unchanged

• A. A-I, B-II, C-III, D-IV
• B. A-IV, B-I, C-III, D-II
• C. A-IV, B-III, C-I, D-II
• D. A-III, B-I, C-II, D-IV

Hint:

Silent = Same AA; Nonsense = Stop; Missense = Mistake (diff AA); Frameshift = Full shift.

Answer 1

The Correct Option is C

Step 1: Concept
Mutations are changes in the DNA sequence that can affect the resulting protein in different ways.

Step 2: Meaning
The type of mutation is defined by its specific effect on the amino acid sequence.

Step 3: Analysis
- Silent (A): Due to redundancy in the genetic code, the DNA change does not change the amino acid (IV). - Missense (B): A single nucleotide change results in a different amino acid (III). - Nonsense (C): A point mutation changes an amino acid codon into a premature stop codon (I). - Frameshift (D): Insertion or deletion shifts the reading frame, changing every amino acid downstream (II).

Step 4: Conclusion
The correct pairs are A-IV, B-III, C-I, D-II. Final Answer: (C)