Question:
Lithium is used for the treatment of ________.
Lithium is used for the treatment of ________.
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Lithium facts:
- Indication: Bipolar disorder.
- Narrow Therapeutic Window: $0.8 - 1.2 \text{ mEq/L}$ (maintenance phase).
- Side effects: Tremors, polyuria (nephrogenic diabetes insipidus), and hypothyroidism.
Updated On: Jul 4, 2026
- convulsions
- bipolar disorder
- parkinson disease
- alzheimer's disease
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The Correct Option is B
Solution and Explanation
Concept:
Lithium ions ($\text{Li}^+$) serve as the classic mood stabilizer in psychiatric medicine. Its primary therapeutic mechanism involves inhibiting the recycling of inositol substrates by blocking the inositol monophosphatase (IMPase) enzyme, which downregulates the overactive phosphatidylinositol ($PIP_2$) signaling pathway inside hyperactive neurons.
Step 1: Identify the primary clinical indication.
Lithium is the gold standard drug for the treatment and prophylaxis of acute mania and the depressive phases associated with bipolar disorder (formerly known as manic-depressive illness). It reduces the frequency and intensity of mood swings.
Step 1: Identify the primary clinical indication.
Lithium is the gold standard drug for the treatment and prophylaxis of acute mania and the depressive phases associated with bipolar disorder (formerly known as manic-depressive illness). It reduces the frequency and intensity of mood swings.
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