Question

Given below are two statements: Statement I: Protein-ligand docking involves binding of a small molecule to the protein receptor. Statement II: Both AUTODOCK and LUDI are protein-ligand docking programs. In the light of the above statements, choose the correct answer from the options given below:

• A. Both Statement I and Statement II are true
• B. Both Statement I and Statement II are false
• C. Statement I is correct but Statement II is false
• D. Statement I is incorrect but Statement II is true

Hint:

• Docking = Ligand + Protein binding prediction
• AUTODOCK → Popular docking tool
• LUDI → Structure-based docking/design

Answer 1

The Correct Option is A

Concept: Protein-ligand docking is a computational technique used to predict how a small molecule (ligand) binds to a protein receptor.
• It helps in drug discovery by predicting binding affinity and orientation.
• Various software tools are available for docking studies.

Step 1: Evaluating Statement I.
Protein-ligand docking indeed involves the interaction between a small molecule (ligand) and a protein receptor. Hence, Statement I is correct.

Step 2: Evaluating Statement II.

• AUTODOCK: A widely used protein-ligand docking software.
• LUDI: Also used for structure-based drug design and docking. Thus, Statement II is correct.

Step 3: Selecting the correct answer.
Since both statements are true, the correct option is (A).