Question:
Assertion (A): Estrogen in oral contraceptive can cause venous thromboembolism. Reason (R): Estrogen reduces plasminogen from liver.
Assertion (A): Estrogen in oral contraceptive can cause venous thromboembolism. Reason (R): Estrogen reduces plasminogen from liver.
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Estrogen is pro-coagulant, making the blood "thicker" and prone to clots.
Updated On: May 25, 2026
- Assertion is true, Reason is false
- Assertion is false, Reason is true
- Both Assertion and Reason are true
- Both Assertion and Reason are false
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The Correct Option is A
Solution and Explanation
Step 1: Concept
Oral contraceptives contain estrogen which influences the coagulation cascade.
Step 2: Meaning
Venous thromboembolism (VTE) involves the formation of blood clots in the veins. Plasminogen is a precursor to plasmin, which helps dissolve clots.
Step 3: Analysis
It is clinically proven that estrogen increases the risk of VTE (Assertion is true). However, estrogen actually tends to increase the synthesis of several coagulation factors and can affect fibrinolysis, but the reasoning that it "reduces plasminogen" to cause clots is incorrect; it often increases certain clotting factors like VII and X.
Step 4: Conclusion
The assertion is a known clinical side effect, but the stated physiological reason is false. Final Answer: (A)
Oral contraceptives contain estrogen which influences the coagulation cascade.
Step 2: Meaning
Venous thromboembolism (VTE) involves the formation of blood clots in the veins. Plasminogen is a precursor to plasmin, which helps dissolve clots.
Step 3: Analysis
It is clinically proven that estrogen increases the risk of VTE (Assertion is true). However, estrogen actually tends to increase the synthesis of several coagulation factors and can affect fibrinolysis, but the reasoning that it "reduces plasminogen" to cause clots is incorrect; it often increases certain clotting factors like VII and X.
Step 4: Conclusion
The assertion is a known clinical side effect, but the stated physiological reason is false. Final Answer: (A)
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