Given below are two statements, one is labelled as Assertion A and the other is labelled as Reason R
Assertion A : The uncompetitive inhibitors bind only to the enzyme-substrate (ES) complex and not to the free enzyme.
Reason R : Binding of the substrate to the enzyme causes a change in its conformation, which reveals the inhibitor-binding site.
In light of the above statements, choose the correct answer from the options given below