List of top Questions asked in ICAR AIEEA (PG)- 2021

Which of the following are correct for proline?
A. It is also called imino acid
B. Its "R"-Group (Side chain) is a hydrogen atom
C. Incorporation of proline in helical structure disrupts the \(\alpha\)-helical structure
D. It contains a free \(\alpha\)-carboxylic acid group and a free \(\alpha\)-amino group
Choose the correct answer from the options given below:

Which of the following statements are correct for pyrimidine deoxyribonucleotides?
A. Nitrogen 1 (N1) of a pyrimidine base is attached to C1' of D-ribose present in the pyrimidine deoxyribonucleotides
B. C5 of a pyrimidine deoxyribonucleosides may attach to one or more phosphate group
C. Base present in pyrimidine deoxyribonucleotide is always complementary to a purine base present in a double-stranded DNA
D. Pyrimidine deoxyribonucleotides are joined together through a phosphodiester bond to form DNA strand
Choose the correct answer from the options given below:

Which of the following are true for an enzyme?
A. Enzyme cannot change the equilibrium constant of a reaction
B. The unique physical and chemical properties of the active site limit an enzyme's activity to a specific substrate
C. Enzyme may require metallic ion and organic cofactor for their proper functioning
D. pH of the reaction mixture does not affect the enzyme activity
Choose the correct answer from the options given below:

If the Vmax of an enzyme is 10 IU and its Km is 20 mM then Lineweaver Burk plot of this enzyme follows a slope of:

Which of the following statements are correct for the Kcat?
A. It is also called turnover number
B. Specificity constant of an enzyme can be calculated from its Kcat and Km
C. Kcat is calculated from the Vmax and number of substrate binding site of an enzyme
D. It can also be calculated from initial substrate concentration and enzyme concentration only
Choose the correct answer from the options given below:

Statement I: The binding site on the enzyme is known as the active site and is structurally complementary to the substrate.
Statement II: Binding of a substrate to an enzyme active site causes a change in the three-dimensional structure of the enzyme which helps to reduce the activation energy of the reaction.
In light of the above statements, choose the most appropriate answer from the options given below:

Following are the data of substrate concentration and the corresponding velocity of an enzyme:
Substrate concentration in mM: 10, 30, 60, 100, 120, 160, 200, 250, 300
Enzyme velocity in IU: 20, 40, 60, 80, 100, 140, 160, 200, 220
On the basis of the above data, Km value of the enzyme is:

In a reaction mixture of enzyme keeping the enzyme concentration and other conditions constant only substrate concentration is changed. The enzyme activity to corresponding substrate concentrations are given below:
Substrate concentration in mM: 2, 5, 10, 15, 20
Enzyme activity in IU: 15, 25, 50, 56, 58
On the basis of the above observation table, the second-order reaction started after the first-order reaction occurred up to a substrate concentration of:

Which type of Inhibition is most noticeable at low substrate concentration, and can be overcome by higher substrate concentration?

During the cell cycle, DNA replication occurs in which phase?

The pH of animal cell tissue culture is usually:

Which of the following disease is sex-linked in human chromosome?

A chromosome with centromere near the middle is called:

The organelle that contains hydrolytic enzymes is:

Which of the following is NOT correct about Mitochondria?

The dimensions of B-DNA are:

Which form of DNA is most commonly found in nature under physiological conditions?

In the structure of a nucleoside, the base is attached to the sugar at which position?

Without histones, unwound DNA in chromosomes would be very long and the length of completely stretched DNA within each human cell would be:

Which of the following histones is NOT part of the nucleosome core?

Which of the following is NOT correct for Z-DNA conformation?

Which of the following is NOT a purine base?

In a hypothetical stage in the evolutionary history of life on Earth, which self-replicating molecules proliferated before the evolution of all molecules?

Gene is:

The largest known gene is in the human being and has 79 exons spanning at least 2,300 kilobases (kb) DNA. It is: