Write the therapeutic use and the animal cell line employed in obtaining any three of the following protein pharmaceuticals:
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Solution and Explanation
(A) Erythropoietin: Therapeutic Use: Erythropoietin is primarily used for the treatment of anemia, especially in patients with kidney disease and those undergoing chemotherapy. Animal Cell Line: The most commonly used animal cell line for production of Erythropoietin is CHO (Chinese Hamster Ovary) cell line.
(B) Herceptin: Therapeutic Use: Herceptin (Trastuzumab) is used for breast cancer therapy, particularly in cases where the cancer cells overexpress the HER2 protein. Animal Cell Line: The production of Herceptin typically involves the CHO cell line.
(C) Interleukin-2: Therapeutic Use: Interleukin-2 is mainly used for treating cancer. Animal Cell Line: The most used cell line for production of Interleukin-2 is CHO cells.
(D) Tissue plasminogen activator (tPA): Therapeutic Use: Tissue plasminogen activator (tPA) is used in treating stroke and dissolves blood clots. Animal Cell Line: tPA is produced using CHO cells.
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