Question:
Which selenoprotein is involved in the conversion of thyroid hormone T\(_4\) into T\(_3\)?
Which selenoprotein is involved in the conversion of thyroid hormone T\(_4\) into T\(_3\)?
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5'-deiodinase: converts T4 to T3.
Selenium-dependent enzyme.
Important for thyroid hormone function.
Selenium-dependent enzyme.
Important for thyroid hormone function.
Updated On: Aug 18, 2026
- Thioredoxin reductase
- Glutathione peroxidase
- Selenophosphate synthetase
- Iodothyronine 5'-deiodinase
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Verified By Collegedunia
The Correct Option is D
Solution and Explanation
Step 1: Understanding the Concept:
Selenium is incorporated into selenoproteins.
These proteins have specific functions.
Step 2: Key Formula or Approach:
No specific formula.
Need to know selenoprotein functions.
Step 3: Detailed Explanation:
Iodothyronine 5'-deiodinase is a selenoprotein.
It converts T\(_4\) (thyroxine) to T\(_3\) (triiodothyronine).
Thioredoxin reductase is involved in redox reactions.
Glutathione peroxidase is an antioxidant enzyme.
Selenophosphate synthetase is involved in selenium metabolism.
Thus, iodothyronine 5'-deiodinase is correct.
Step 4: Final Answer:
Iodothyronine 5'-deiodinase converts T\(_4\) to T\(_3\).
Hence, the correct option is (D).
Selenium is incorporated into selenoproteins.
These proteins have specific functions.
Step 2: Key Formula or Approach:
No specific formula.
Need to know selenoprotein functions.
Step 3: Detailed Explanation:
Iodothyronine 5'-deiodinase is a selenoprotein.
It converts T\(_4\) (thyroxine) to T\(_3\) (triiodothyronine).
Thioredoxin reductase is involved in redox reactions.
Glutathione peroxidase is an antioxidant enzyme.
Selenophosphate synthetase is involved in selenium metabolism.
Thus, iodothyronine 5'-deiodinase is correct.
Step 4: Final Answer:
Iodothyronine 5'-deiodinase converts T\(_4\) to T\(_3\).
Hence, the correct option is (D).
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