Question

Which one of the following is a drug interaction at absorption site?

• A. Alteration in the motility of the GIT
• B. Alteration in the metabolism
• C. Alteration in drug protein binding
• D. Enzyme inhibition

Hint:

Absorption = Gut. Motility = How fast things move through the gut.

Answer 1

The Correct Option is A

Step 1: Concept
Pharmacokinetic interactions can happen at any stage: Absorption, Distribution, Metabolism, or Excretion.

Step 2: Meaning
Interactions at the absorption site affect how much or how fast a drug enters the bloodstream from the gut.

Step 3: Analysis
Protein binding is an interaction during Distribution. Metabolism and Enzyme inhibition are part of the Metabolism phase. Changing the motility of the Gastrointestinal Tract (GIT) directly impacts how a drug is absorbed.

Step 4: Conclusion
Thus, altering GIT motility is a classic example of a drug interaction occurring at the absorption site.

Final Answer: (A)